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The Leader in Spatial Biology

Spatial LifeStrands CosMx Spatial Molecular Imager
Spatial LifeStrands CosMx Spatial Molecular Imager
NanoString logo

The Leader in Spatial Biology

About Our Technology

The CosMx SMI platform is the pioneering high-plex in-situ analysis tool that offers spatial multiomics for both FFPE and FF tissue samples at the cellular and subcellular levels. With up to 1,000 RNA and 64 validated protein analytes, CosMx SMI allows for quick quantification and visualization.

With the CosMx Spatial Molecular Imager (SMI), scientists can create comprehensive maps of individual cells within their natural environment. This technology enables researchers to gain a deeper understanding of various cell types, their behaviors and functions, ultimately enhancing our ability to interpret biological processes and diseases from a single experiment.

How does CosMx work?

The CosMx SMI is a comprehensive system that features advanced cyclic fluorescent in-situ hybridization (FISH) chemistry, high-quality imaging output, interactive data analysis and visualization software. Its workflow is efficient and easy-to-use, and it seamlessly integrates with standard ISH protocols without requiring tissue expansion or clearing, cDNA synthesis, or amplification. With the CosMx SMI, you can achieve faster results from your samples.
How does CosMx work?

Why choose CosMx?

The CosMx™ system is designed for spatial profiling of gene expression in tissues. It combines the capabilities of traditional histology with high-plex RNA profiling at single-cell resolution. Here are some advantages of the CosMx™ Spatial Molecular Imager:

Spatially Resolved Gene Expression: The CosMx™ system enables researchers to visualize gene expression patterns within intact tissue sections, providing spatial context for cellular behavior and interactions.

Single-Cell Resolution: It allows the identification and characterization of individual cells within a tissue, enabling a deeper understanding of cellular heterogeneity and complex biological processes.

High-Plex RNA Profiling: With the use of NanoString’s barcoding technology, the CosMx™ system can simultaneously measure the expression of hundreds of genes in a single tissue section, allowing comprehensive molecular profiling.

Multiplexed Imaging: The CosMx™ system enables the detection of multiple RNA targets within a single tissue section, providing a wealth of information on gene expression patterns and interactions.

Easy Workflow: The system offers an integrated workflow from tissue processing to data analysis, streamlining the experimental process and allowing researchers to focus on data interpretation and biological insights.

High-plex
assays

More cell types, cell states and biological pathways

Any Sample
types

More cell types, cell states and biological pathways

High
Sensitivity

Single-cell analysis at subcellular resolution

Spatial
Multiomics

One system for
RNA and protein

AtoMx™ Spatial
Informatics Platform

An integrated informatics solution, AtoMx SIP enables scalable data analysis, storage, and sharing

True Single-Cell
Segmentation

Uses multi-modal cell segmentation which provides accurate cell boundaries detection

Why choose CosMx?

High-plex
assays

More cell types, cell states and biological pathways

Any Sample
types

More cell types, cell states and biological pathways

High
Sensitivity

Single-cell analysis at subcellular resolution

Spatial
Multiomics

One system for
RNA and protein

AtoMx™ Spatial
Informatics Platform

An integrated informatics solution, AtoMx SIP enables scalable data analysis, storage, and sharing

True Single-Cell Segmentation

Uses multi-modal cell segmentation which provides accurate cell boundaries detection

Applications

CosMx Spatial Molecular Imager is the most flexible
and robust spatial single-cell imaging platform for
Spatial LifeStrands

Cell Atlas and
Characterization

Define cell types, cell states, tissue microenvironment phenotypes, and gene expression networks within spatial context.
Spatial LifeStrands

Biomarker
Discovery

Reveal differential gene expression and pathways in the same cell types depending on their spatial location.
Spatial LifeStrands

Disease
State

Visualize and quantify molecular (RNA / protein) and cellular organizational changes in a tissue.
Spatial LifeStrands

Tissue
Microenvironment

Understand cellular neighborhoods by examining individual cells and their interacting neighboring cells.
Spatial LifeStrands

Ligand-Receptor
Interaction

Analyze expression and interactions of up to 100 classic ligand-receptor pairs between interacting cells.
Spatial LifeStrands

Spatial
Biomarkers

Quantify change in gene expression based on treatment and identify single-cell subcellular biomarkers with spatial context.

Panel Assays

Flexible options to cover your research needs
CosMx Custom Solutions Panel

CosMx
Custom
Solutions Panel

CosMx Human Universal Cell Characterization Panel (RNA, 1000 Plex)

CosMx Human Universal Cell Characterization Panel (RNA, 1000 Plex)

CosMx Human Immuno-oncology Panel (RNA, 100 Plex)

CosMx Human Immuno-oncology Panel (RNA, 100 Plex)

CosMx Mouse Neuroscience Panel (RNA, 1000 Plex)

CosMx Mouse Neuroscience Panel (RNA, 1000 Plex)

CosMx Human Immuno-oncology Panel (Protein, 64 Plex)

CosMx Human Immuno-oncology Panel (Protein, 64 Plex)

Analysis

LifeStrands provides all customers a one-stop solution to all their spatial
needs by having an in-house bioinformatician to aid you with their research.

Introducing AtoMx™ Spatial Informatics Platform (SIP)

The only cloud-based, fully-integrated informatics platform for spatial biology. Will be used for all Nanostring technologies. With advanced analytics enabling global data sharing and collaboration, ​AtoMx SIP helps researchers analyze large amounts of spatial multiomics data anytime, anywhere.​
  • NanoString Spatial Platform IntergrationStream image and count files seamlessly from CoxMx SMI and GeoMx DSP into AtoMx SIP.
  • Data ManagementSecurely store, manage, and collaborate spatial multiomics data around the globe.
  • Analyze & Visualize Spatial DataPerform secondary analysis and tertiary analysis with preconfigured modules and data analysis pipelines.
  • Customer AnalysisEdit pre-built modules and pipelines OR build custom module and pipelines to analyze spatial data to fit your needs.*
  • Security & ComplianceSingle Sign-On authentication backed by standard-compliant data encryption for data-in0transit and data-at-rest through Amazon Web Services.
  • NanoString Spatial Platform IntergrationStream image and count files seamlessly from CoxMx SMI and GeoMx DSP into AtoMx SIP.
  • Data ManagementSecurely store, manage, and collaborate spatial multiomics data around the globe.
  • Analyze & Visualize Spatial DataPerform secondary analysis and tertiary analysis with preconfigured modules and data analysis pipelines.
  • Customer AnalysisEdit pre-built modules and pipelines OR build custom module and pipelines to analyze spatial data to fit your needs.*
  • Security & ComplianceSingle Sign-On authentication backed by standard-compliant data encryption for data-in0transit and data-at-rest through Amazon Web Services.

Our Other Technologies

Spatial LifeStrands
Visium from 10x Genomics is a spatial discovery platform that allows whole transcriptome profiling of fresh and formalin fixed paraffin-embedded (FFPE) tissues.
Spatial LifeStrands 8
NanoString's GeoMx Digital Spatial Profiler (DSP) is a technology that enables comprehensive spatial and molecular analysis of RNA and protein in tissue samples on glass slides.

Find Out More About Our Services.