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Advancement Clinical HistopathologySpatial LifeStrands

In the past ten years, the introduction of high throughput digital scanning microscopes and advancements in next-generation-sequencing have created new opportunities in the field of digital pathology. These developments have caused significant changes and paradigm shifts in histopathology.

Currently, NanoString and 10X Genomics are two leading companies offering tools to academics and researchers for early access to spatial transcriptomics.Spatial LifeStrands

Clinical Histopathology
Histopathology serves as a definitive diagnostic method due to the fact that many illnesses are identified by abnormal spatial organization within tissue. Factors such as uncontrolled cellular proliferation, fibrosis, angiogenesis, infections, and inflammatory responses can alter the cellular and extracellular makeup of the tissue.Spatial LifeStrands

About Spatial Genomics

Spatial Biology is a novel field in molecular biology that focuses on examining tissues within their 2D or 3D environment. In the same way that GPS captures location coordinates within an area to create a map and track you within it. With advances in technology and computational analysis, spatial genomics has the potential to revolutionize our understanding of biology and human health.Spatial LifeStrands

What can I expect?

By utilizing this technology, we can effectively delineate the spatial structure of a cell and its communication and interaction with its environment. This is accomplished by breaking down seemingly homogeneous regions into unique molecular signatures and pinpointing relevant cell types, resulting in the production of precise and reliable data that can be easily visualized.Spatial LifeStrands

What is it like?

Spatial biology provides a view of a tissue sample at a molecular level, allowing for observations that cannot be achieved through sequencing or other existing technologies.Spatial LifeStrands

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How Can Spatial Genomics Translate to Biological Discovery?

At Spatial LifeStrands, we are confident that our advanced spatial analysis will revolutionize fundamental biology, precision medicine, drug development, and diagnostics.

Spatial genomics aims to bridge this gap by generating highly detailed maps of gene expression within individual cells or small clusters of cells, allowing researchers to identify previously unknown cellular subtypes and functional relationships between different cell types.Spatial LifeStrands

By combining this information with traditional genomic data, scientists can gain a deeper understanding of biological processes such as development, disease progression, and response to treatments. Check out some real-world examples of how our technologies are being used:

Fundamental Biology

As technology advances and becomes more applicable, GeoMx and Visium can be used to identify variations in cell clustering morphology transcriptome. These differences may play a crucial role in determining suitable treatment options.

Drug Development

With high throughput, you have the ability to simultaneously examine RNA and protein changes in your samples before and after treatment. This allows you to identify variances in cell types or conduct comprehensive coverage of your sample without any exclusions.

Diagnostics/Biomarker Discovery

Our technology allows you to customize your gene list by targeting up to 18,800+ genes. With the capacity to process 30 samples per week, you can create personalized biomarker groups tailored to your specific disease case.

Precision Medicine

Using GeoMx and Visium, you can fish out differences in cell clustering, morphology or transcriptome which could determine potential treatment options as technology advances and becomes more applicable.

Featured Work

Breast Cancer
Case Study

Protein / WTA
(Rectum B)

Visium
(Rectum B)

Certified Service Provider

Spatial LifeStrands Certified Service Providers - 10x Genomics
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